CD1 expression is not affected by human peptide transporter deficiency
D Hanau, D Fricker, T Bieber, ME Esposito-Farese… - Human immunology, 1994 - Elsevier
Conventional major histocompatibility complex class I molecules are highly polymorphic and
present peptides to cytotoxic T cells. These peptides derive from the proteolytic degradation
of endogenous proteins in the cytosol and are translocated into the endoplasmic reticulum
by a peptide transporter consisting of two transporter associated with antigen processing
(TAP) molecules. Absence of this transporter leads to the synthesis of unstable peptide free
class I molecules that are weakly expressed on the cell surface. Mouse nonconventional …
present peptides to cytotoxic T cells. These peptides derive from the proteolytic degradation
of endogenous proteins in the cytosol and are translocated into the endoplasmic reticulum
by a peptide transporter consisting of two transporter associated with antigen processing
(TAP) molecules. Absence of this transporter leads to the synthesis of unstable peptide free
class I molecules that are weakly expressed on the cell surface. Mouse nonconventional …
