Tolerance of NK and LAK activity for HLA class I-deficient targets in a TAP1-deficient patient (bare lymphocyte syndrome type I)
H Furukawa, T Yabe, K Watanabe, R Miyamoto… - Human immunology, 1999 - Elsevier
NK cells recognize target cells that lack HLA class I molecules and lyse them, according to
the 'missing self'hypothesis. It was previously reported that a TAP2-deficient patient with an
HLA class I-deficiency, had a normal number of NK cells but that the lymphocytes of this
patient had lost their NK activity against K562 cells.[1] In this study, we investigated the HLA
class I-recognizing NK receptor expressions and the NK and LAK activities of the
lymphocytes of a TAP1-deficient patient. The patient had a normal number of NK cells …
the 'missing self'hypothesis. It was previously reported that a TAP2-deficient patient with an
HLA class I-deficiency, had a normal number of NK cells but that the lymphocytes of this
patient had lost their NK activity against K562 cells.[1] In this study, we investigated the HLA
class I-recognizing NK receptor expressions and the NK and LAK activities of the
lymphocytes of a TAP1-deficient patient. The patient had a normal number of NK cells …