Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions …
RK Tangirala, EM Rubin, W Palinski - Journal of lipid research, 1995 - ASBMB
Murine strains susceptible to atherosclerosis provide valuable models to study factors
involved in atherogenesis. In some murine models, limited hypercholesterolemia can be
achieved and lesions develop primarily in the aortic origin, in the vicinity of the aortic valve.
In other models such as LDL receptor-deficient and apoE-deficient mice, diet-induced or
spontaneous hypercholesterolemia and atherogenesis are much greater. To determine
whether lesion formation in the aortic origin, where particular pathogenic conditions may …
involved in atherogenesis. In some murine models, limited hypercholesterolemia can be
achieved and lesions develop primarily in the aortic origin, in the vicinity of the aortic valve.
In other models such as LDL receptor-deficient and apoE-deficient mice, diet-induced or
spontaneous hypercholesterolemia and atherogenesis are much greater. To determine
whether lesion formation in the aortic origin, where particular pathogenic conditions may …