[CITATION][C] Crystal structure of human cathepsin K complexed with a potent inhibitor
ME McGrath, JL Klaus, MG Barnes… - Nature structural biology, 1997 - nature.com
ME McGrath, JL Klaus, MG Barnes, D Brömme
Nature structural biology, 1997•nature.comcomplexed with a potent inhibitor Page 1 TG) 1997 Nature Publishing Group http://www.nature.com/nsmb
correspondence Crystal structure of human cathepsin K complexed with a potent inhibitor The
high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent
mechanism-based inhibitor, APC3328, reveals the substrate-binding sites of this cysteine
proteinase and validates the binding mode for this inhibitor class. Sir–A careful balance
between osteoclast and osteoblast activity is responsible for the normal bone remodelling …
correspondence Crystal structure of human cathepsin K complexed with a potent inhibitor The
high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent
mechanism-based inhibitor, APC3328, reveals the substrate-binding sites of this cysteine
proteinase and validates the binding mode for this inhibitor class. Sir–A careful balance
between osteoclast and osteoblast activity is responsible for the normal bone remodelling …
The high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent mechanism-based inhibitor, APC3328, reveals the substrate-binding sites of this cysteine proteinase and validates the binding mode for this inhibitor class.
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