Effect of intermittent altitude hypoxia on the myocardium and lesser circulation in the rat
J Widimský, D Urbanova, J Ressl… - Cardiovascular …, 1973 - academic.oup.com
J Widimský, D Urbanova, J Ressl, B Ošťádal, V Pelouch, J Prochazka
Cardiovascular Research, 1973•academic.oup.comAUTHORS'SYNOPSIS The effect of intermittent altitude hypoxia on the myocardium and
lesser circulation was investigated in 58 rats. The altitude hypoxia was produced with a low
pressure chamber (7,000 m, five days a week, four hours daily). This type of intermittent
altitude hypoxia led to right ventricular hypertrophy in all animals after 24 exposures. A
chronic pulmonary hypertension of a moderate degree was found even after intermittent
altitude hypoxia (75 exposures). In this study, histological changes (focal necroses in both …
lesser circulation was investigated in 58 rats. The altitude hypoxia was produced with a low
pressure chamber (7,000 m, five days a week, four hours daily). This type of intermittent
altitude hypoxia led to right ventricular hypertrophy in all animals after 24 exposures. A
chronic pulmonary hypertension of a moderate degree was found even after intermittent
altitude hypoxia (75 exposures). In this study, histological changes (focal necroses in both …
AUTHORS' SYNOPSIS
The effect of intermittent altitude hypoxia on the myocardium and lesser circulation was investigated in 58 rats. The altitude hypoxia was produced with a low pressure chamber (7,000 m, five days a week, four hours daily). This type of intermittent altitude hypoxia led to right ventricular hypertrophy in all animals after 24 exposures. A chronic pulmonary hypertension of a moderate degree was found even after intermittent altitude hypoxia (75 exposures). In this study, histological changes (focal necroses in both left and right ventricle) were observed.
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