[HTML][HTML] Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

PJ Lee, BH Jiang, BY Chin, NV Iyer, J Alam… - Journal of Biological …, 1997 - ASBMB
Exposure of rats to hypoxia (7% O 2) markedly increased the level of heme oxygenase-1
(HO-1) mRNA in several tissues. Accumulation of HO-1 transcripts was also observed after
exposure of rat aortic vascular smooth muscle (VSM) cells to 1% O 2, and this induction was
dependent on gene transcription. Activation of the mouse HO-1 gene by all agents thus far
tested is mediated by two 5′-enhancer sequences, SX2 and AB1, but neither fragment was
responsive to hypoxia in VSM cells. Hypoxia-dependent induction of the chloramphenicol …