[HTML][HTML] Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology
AF Clark, MGF Sharp, SD Morley, S Fleming… - Journal of Biological …, 1997 - ASBMB
The secretion of renin from granules stored in renal juxtaglomerular cells plays a key role in
blood pressure homeostasis. The synthesis and release of renin and the extent of
granulation is regulated by several mechanisms including signaling from the macula densa,
neuronal input, and blood pressure. Through the use of a gene-targeting vector containing
homology arms generated using the polymerase chain reaction, we have inactivated theRen-
1 d gene, one of two mouse genes encoding renin, and report that lack of renin-1 d results in …
blood pressure homeostasis. The synthesis and release of renin and the extent of
granulation is regulated by several mechanisms including signaling from the macula densa,
neuronal input, and blood pressure. Through the use of a gene-targeting vector containing
homology arms generated using the polymerase chain reaction, we have inactivated theRen-
1 d gene, one of two mouse genes encoding renin, and report that lack of renin-1 d results in …