P-selectin is a leukocyte adhesion molecule present on the surfaces of activated platelets
and endothelial cells. Its expression has been documented at sites of active inflammation
including that resulting from cardiovascular disease. Mice deficient in P-selectin, generated
by gene targeting, have provided tools for understanding the role of P-selectin in mediating
the complex processes that lead to leukocyte extravasation in inflammatory processes. This
review discusses the generation and characterization of P-selectin-deficient mice and our …