Structure and function of neuronal nicotinic acetylcholine receptors

J Lindstrom, R Anand, V Gerzanich, X Peng… - Progress in brain …, 1996 - Elsevier
Publisher Summary This chapter discusses some aspects of neuronal acetylcholine
receptors (AChRs), reviews some of the recent studies of the mechanism by which chronic
exposure to nicotine affects aα4β2 AChRs, and describes some of the pharmacological
properties of neuronal AChRs, especially the differences between α7 and α8 AChRs and the
usefulness of epibatidine (exo-2-(6-chloro-3-pyridyl)-7-azabicyclo-[2.2. l]-heptane) as a
ligand for many types of neuronal AChRs. The basic homologies in structure of receptors in …