Experimental studies indicate that Angll is involved in the process of tissue destruction in
chronic renal diseases. This notion has been verified in a number of small-to large-scale
clinical studies using angiotensin (ANG) I converting enzyme inhibitors (ACEI). Although the
repertoire of the pathophysiologic cascade underlying the progressive destruction of renal
tissue has continued to expand over recent years, from proteinuria and physical forces to
growth factors and metalloproteinase disregulations, studies now suggest that Angll is …