Sperm, nuclear, phospholipid, and red blood cell antibodies and isotype RF in infertile couples and patients with autoimmune rheumatic diseases
R Fichorova, L Nakov, M Baleva… - American Journal of …, 1996 - Wiley Online Library
R Fichorova, L Nakov, M Baleva, K Nikolov, I Gegova
American Journal of Reproductive Immunology, 1996•Wiley Online LibraryPROBLEM: To determine if measuring of nonorgan‐specific autoantibodies is useful for
better understanding and management of unexplained infertility. METHODS: Sera were
obtained from 70 infertile couples, 57 rheumatic patients, and 76 fertile donors. Sperm
antibodies (SA) were detected by the tests of Kibrick and Friberg, anti‐histones, anti‐
cardiolipin antibodies, and RF isotypes by ELISA, antinuclear antibodies by indirect
immunofluorescence, and anti‐red blood cell antibodies by Capture‐R. RESULTS: Multiple …
better understanding and management of unexplained infertility. METHODS: Sera were
obtained from 70 infertile couples, 57 rheumatic patients, and 76 fertile donors. Sperm
antibodies (SA) were detected by the tests of Kibrick and Friberg, anti‐histones, anti‐
cardiolipin antibodies, and RF isotypes by ELISA, antinuclear antibodies by indirect
immunofluorescence, and anti‐red blood cell antibodies by Capture‐R. RESULTS: Multiple …
PROBLEM: To determine if measuring of nonorgan‐specific autoantibodies is useful for better understanding and management of unexplained infertility.
METHODS: Sera were obtained from 70 infertile couples, 57 rheumatic patients, and 76 fertile donors. Sperm antibodies (SA) were detected by the tests of Kibrick and Friberg, anti‐histones, anti‐cardiolipin antibodies, and RF isotypes by ELISA, antinuclear antibodies by indirect immunofluorescence, and anti‐red blood cell antibodies by Capture‐R.
RESULTS: Multiple autoimmune reactivity (both partners positive and/or more than one type of autoantibody involved), higher than naturally occurring in fertile individuals, was found in 55% of the idiopathically infertile couples. IgA‐RF was the dominant autoimmune marker. SA revealed similar rates in patients with rheumatic diseases and in infertiles with or without other autoantibodies.
CONCLUSION: Although no single autoimmunity marker could predict occurrence of SA, the coincidence of enhanced polyclonal autoimmunity in both partners of infertile couples might potentiate their negative effect on reproduction.
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