We studied the effect of the prostaglandin synthesis inhibitor, indomethacin, on pentagastrin-
associated enhancements of gastric mucosal defense mechanisms, using a
microfluorometric technique in which mucus gel thickness, intracellular pH (pHi), gastric
mucosal blood flow, and acid secretion were measured simultaneously in vivo. Intravenous
infusion with pentagastrin (80 μg/kg/h) increased mucus gel thickness, induced a hyperemic
response to luminal acid, and enhanced pHi homeostasis during acid superfusion …