Generation and TAP-mediated transport of peptides for major histocompatibility complex class I molecules
F Momburg, GJ Hämmerling - Advances in immunology, 1998 - Elsevier
Publisher Summary This chapter reviews the generation and TAP-mediated transport of
peptides for major histocompatibility complex class I molecules. The translocation of
peptides into the endoplasmic reticulum (ER) is achieved by the transporter associated with
antigen processing (TAP transporter), which belongs to a large family of membrane
translocators containing an ATP-binding cassette. The peptide transporter TAP is thus a
crucial link among the peptide generation machinery in the cytosol, the proteasome, and the …
peptides for major histocompatibility complex class I molecules. The translocation of
peptides into the endoplasmic reticulum (ER) is achieved by the transporter associated with
antigen processing (TAP transporter), which belongs to a large family of membrane
translocators containing an ATP-binding cassette. The peptide transporter TAP is thus a
crucial link among the peptide generation machinery in the cytosol, the proteasome, and the …