[HTML][HTML] Cathepsin K, but Not Cathepsins B, L, or S, is abundantly expressed in human osteoclasts (∗)
FH Drake, RA Dodds, IE James, JR Connor… - Journal of Biological …, 1996 - ASBMB
Random high throughput sequencing of a human osteoclast cDNA library was employed to
identify novel osteoclast-expressed genes. Of the 5475 ESTs obtained, approximately 4%
encoded cathepsin K, a novel cysteine protease homologous to cathepsins S and L; ESTs
for other cathepsins were rare. In addition, ESTs for cathepsin K were absent or at low
frequency in cDNA libraries from numerous other tissues and cells. In situ hybridization in
osteoclastoma and osteophyte confirmed that cathepsin K mRNA was highly expressed …
identify novel osteoclast-expressed genes. Of the 5475 ESTs obtained, approximately 4%
encoded cathepsin K, a novel cysteine protease homologous to cathepsins S and L; ESTs
for other cathepsins were rare. In addition, ESTs for cathepsin K were absent or at low
frequency in cDNA libraries from numerous other tissues and cells. In situ hybridization in
osteoclastoma and osteophyte confirmed that cathepsin K mRNA was highly expressed …