T-cell regeneration: all repertoires are not created equal

CL Mackall, FT Hakim, RE Gress - Immunology today, 1997 - cell.com
CL Mackall, FT Hakim, RE Gress
Immunology today, 1997cell.com
The importance of the thymus for T-cell development is a central tenet of modern
immunology, but thymic-independent T-cell generation has also been described. Recent
human studies have shown that the balance between thymic-dependent and thymic-
independent pathways of T-cell regeneration is primarily determined by age, and that thymic-
independent pathways are generally inadequate for restoration of host immunocompetence.
Abstract
The importance of the thymus for T-cell development is a central tenet of modern immunology, but thymic-independent T-cell generation has also been described. Recent human studies have shown that the balance between thymic-dependent and thymic-independent pathways of T-cell regeneration is primarily determined by age, and that thymic-independent pathways are generally inadequate for restoration of host immunocompetence.
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