[HTML][HTML] Isoleukotrienes are biologically active free radical products of lipid peroxidation
KA Harrison, RC Murphy - Journal of Biological Chemistry, 1995 - ASBMB
The free radical oxidation of arachidonic acid esterified to glycerophospholipids is known to
generate complex metabolites, termed isoprostanes, that share structural features of
prostaglandins derived from prostaglandin H 2 synthase. Furthermore, certain isoprostanes
have been found to exert biological activity through endogenous receptors on cell surfaces.
Using mass spectrometry and ancillary techniques, the free radical oxidation of 1-
hexadecanoyl-2-arachidonoyl-glycerophosphocholine was studied in the search for …
generate complex metabolites, termed isoprostanes, that share structural features of
prostaglandins derived from prostaglandin H 2 synthase. Furthermore, certain isoprostanes
have been found to exert biological activity through endogenous receptors on cell surfaces.
Using mass spectrometry and ancillary techniques, the free radical oxidation of 1-
hexadecanoyl-2-arachidonoyl-glycerophosphocholine was studied in the search for …