ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Lex
ML Phillips, E Nudelman, FCA Gaeta, M Perez… - Science, 1990 - science.org
ML Phillips, E Nudelman, FCA Gaeta, M Perez, AK Singhal, SI Hakomori, JC Paulson
Science, 1990•science.orgRecruitment of neutrophils to sites of inflammation is mediated in part by endothelial
leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells
of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of
adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In
this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand,
sialyl-Lewis X (SLex; NeuAcα2, 3Galβ 1, 4 (Fucα1, 3)-GlcNAc-), a terminal structure found …
leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells
of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of
adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In
this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand,
sialyl-Lewis X (SLex; NeuAcα2, 3Galβ 1, 4 (Fucα1, 3)-GlcNAc-), a terminal structure found …
Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAcα2,3Galβ 1,4(Fucα1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.
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