Molecular basis for plasma alpha (1, 3)-fucosyltransferase gene deficiency (FUT6).
R Mollicone, I Reguigne, A Fletcher, A Aziz… - Journal of Biological …, 1994 - ASBMB
While most humans express an alpha (1, 3)-fucosyltransferase in plasma, 9% of individuals
on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of these
plasma alpha (1, 3)-fucosyltransferase-deficient individuals have Lewis negative phenotype
on red cells, suggesting strong linkage disequilibrium between these two traits. To define the
molecular basis for this plasma deficiency and to determine which of two candidate human
alpha (1, 3)-fucosyltransferase genes encode this enzyme (FUT5 and FUT6), we cloned and …
on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of these
plasma alpha (1, 3)-fucosyltransferase-deficient individuals have Lewis negative phenotype
on red cells, suggesting strong linkage disequilibrium between these two traits. To define the
molecular basis for this plasma deficiency and to determine which of two candidate human
alpha (1, 3)-fucosyltransferase genes encode this enzyme (FUT5 and FUT6), we cloned and …