[HTML][HTML] Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco (endo) plasmic reticulum …
LH Liu, RJ Paul, RL Sutliff, ML Miller, JN Lorenz… - Journal of Biological …, 1997 - ASBMB
Sarco (endo) plasmic reticulum Ca 2+ ATPase isoform 3 (SERCA3) is one of two Ca 2+
pumps serving intracellular Ca 2+ signaling pools in non-muscle tissues; however, unlike
the ubiquitous SERCA2b, it exhibits a restricted cell-type distribution. Gene targeting was
used to generate a mouse with a null mutation in the SERCA3 gene. Homozygous mutant
mice were viable, fertile, and did not exhibit an overt disease phenotype. Because SERCA3
is expressed in arterial endothelial cells, aortic ring preparations were analyzed to …
pumps serving intracellular Ca 2+ signaling pools in non-muscle tissues; however, unlike
the ubiquitous SERCA2b, it exhibits a restricted cell-type distribution. Gene targeting was
used to generate a mouse with a null mutation in the SERCA3 gene. Homozygous mutant
mice were viable, fertile, and did not exhibit an overt disease phenotype. Because SERCA3
is expressed in arterial endothelial cells, aortic ring preparations were analyzed to …