Paracetamol-stimulated lipid peroxidation in isolated rat and mouse hepatocytes
E Albano, G Poli, E Chiarpotto, F Biasi… - Chemico-biological …, 1983 - Elsevier
Abstract Treatment of isolated hepatocytes from 3-methylcholanthrene induced rats with 1
mM paracetamol has been found to greatly decrease cellular reduced glutathione (GSH)
content and to promote lipid peroxidation, evaluated as malonaldehyde (MDA) production
and conjugated diene absorbance. A similar dosing of hepatocytes from phenobarbital-
induced or normal rats is ineffective in that respect. On the other hand, the aspecific
stimulation of the cytochrome P-450-mediated paracetamol activation due to acetone …
mM paracetamol has been found to greatly decrease cellular reduced glutathione (GSH)
content and to promote lipid peroxidation, evaluated as malonaldehyde (MDA) production
and conjugated diene absorbance. A similar dosing of hepatocytes from phenobarbital-
induced or normal rats is ineffective in that respect. On the other hand, the aspecific
stimulation of the cytochrome P-450-mediated paracetamol activation due to acetone …