Brain CCK receptors: species differences in regional distribution and selectivity
JA Williams, KA Gryson, DJ McChesney - Peptides, 1986 - Elsevier
The binding of 125 I-CCK-33 to its receptors prepared from cerebral cortex and cerebellum
was studied in four species: mouse, rat, hamster, and guinea pig. Only the guinea pig
showed significant binding to membranes from cerebellum and this binding was comparable
to that observed for cerebral cortex. In all four species, the order of potency of unlabeled
analogs to compete for the binding site was CCK-8> CCK-33> desulfated CCK-8> CCK-4.
While the affinity for CCK-8 and CCK-33 was similar in the various species, the relative …
was studied in four species: mouse, rat, hamster, and guinea pig. Only the guinea pig
showed significant binding to membranes from cerebellum and this binding was comparable
to that observed for cerebral cortex. In all four species, the order of potency of unlabeled
analogs to compete for the binding site was CCK-8> CCK-33> desulfated CCK-8> CCK-4.
While the affinity for CCK-8 and CCK-33 was similar in the various species, the relative …