The cholecystokinin receptor antagonist L364, 718 increases food intake in the rat by attenuation of the action of endogenous cholecystokinin
G Hewson, GE Leighton, RG Hill… - British journal of …, 1988 - Wiley Online Library
G Hewson, GE Leighton, RG Hill, J Hughes
British journal of pharmacology, 1988•Wiley Online Library1 To determine the role of endogenous cholecystokinin (CCK) in the regulation of food
intake, the effects of the potent CCK receptor antagonist L364, 718 were investigated on the
intake of a palatable diet in non‐deprived rats. The effect of a single dose of proglumide was
also investigated for comparative purposes. In addition, the ability of L364, 718 to
antagonize the reduction in food intake produced by exogenous cholecystokinin‐
octapeptide (CCK8) or bombesin in food‐deprived rats was determined. 2 L364, 718 (10 …
intake, the effects of the potent CCK receptor antagonist L364, 718 were investigated on the
intake of a palatable diet in non‐deprived rats. The effect of a single dose of proglumide was
also investigated for comparative purposes. In addition, the ability of L364, 718 to
antagonize the reduction in food intake produced by exogenous cholecystokinin‐
octapeptide (CCK8) or bombesin in food‐deprived rats was determined. 2 L364, 718 (10 …
- 1To determine the role of endogenous cholecystokinin (CCK) in the regulation of food intake, the effects of the potent CCK receptor antagonist L364,718 were investigated on the intake of a palatable diet in non‐deprived rats. The effect of a single dose of proglumide was also investigated for comparative purposes. In addition, the ability of L364,718 to antagonize the reduction in food intake produced by exogenous cholecystokinin‐octapeptide (CCK8) or bombesin in food‐deprived rats was determined.
- 2L364,718 (10–100 μg kg−1, i.p.) increased the intake of palatable diet during the 30 min test period. Proglumide (300 mg kg−1, i.p.) also increased the intake of palatable diet. Conversely, CCK8 (0.5–5 μg kg−1, i.p.) produced a reduction in the intake of the diet.
- 3In fasted rats, L364,718 (100 μg kg−1, i.p.) antagonized the reduction in food intake produced by CCK8 (10 μg kg−1, i.p.) but not that produced by bombesin (50 μg kg−1, i.p.). L364,718 did not increase food intake in these animals when measured over a 6 h period.
- 4It is concluded that L364,718 is a potent, selective antagonist of the effects of CCK8 on food intake. The observation that L364,718 and proglumide increase the intake of a palatable diet provides some evidence that endogenous CCK is involved in the control of food intake in this model.
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