Distinctive expression of Iprcg in the heterozygous state on different genetic backgrounds
Y Ogata, M Kimura, K Shimada, T Wakabayashi… - Cellular …, 1993 - Elsevier
Much knowledge of the etiopathogenesis of human autoimmune diseases has been
obtained from the mutant mouse models carrying lpr and gld. These autoimmune genes
have been regarded as autosomal recessive. The novel lymphoproliferative and
autoimmune mutation Ipr cg is unique in its interaction with gld despite their different
chromosomal locations; chromosomes 19 and I, respectively. Both lpr cg and lpr mutations
are shown to be the defects in the Fas antigen gene that controls apoptosis. Evidence has …
obtained from the mutant mouse models carrying lpr and gld. These autoimmune genes
have been regarded as autosomal recessive. The novel lymphoproliferative and
autoimmune mutation Ipr cg is unique in its interaction with gld despite their different
chromosomal locations; chromosomes 19 and I, respectively. Both lpr cg and lpr mutations
are shown to be the defects in the Fas antigen gene that controls apoptosis. Evidence has …