Gelsolin is localized in neuronal growth cones
J Tanaka, M Kira, K Sobue - Developmental brain research, 1993 - Elsevier
Abstract Gelsolin, a Ca 2+-sensitive actin filament-severing protein, is involved in actin
turnover. Immunocytochemical study with anti-gelsolin antibody revealed that the protein is
localized in both filopodia and the body part of growth cones of differentiated PC12 cells with
nerve growth factor (NGF) and of rat dorsal root ganglion neurons. Here, we identified
gelsolin as one of the molecular bases for the Ca 2+-dependent movement of growth cones.
turnover. Immunocytochemical study with anti-gelsolin antibody revealed that the protein is
localized in both filopodia and the body part of growth cones of differentiated PC12 cells with
nerve growth factor (NGF) and of rat dorsal root ganglion neurons. Here, we identified
gelsolin as one of the molecular bases for the Ca 2+-dependent movement of growth cones.