Intrahepatic assembly of very low density lipoproteins. Varied synthetic response of individual apolipoproteins to fasting.
RA Davis, JR Boogaerts, RA Borchardt… - Journal of Biological …, 1985 - ASBMB
Hepatocytes obtained from rats fed for 3 days chow (control) or drinking water only (fasted)
were used to examine how metabolic state affects lipogenesis, apolipoprotein synthesis,
and the capacity to secrete de novo synthesized triacylglycerol. The secretion of
triacylglycerol (mass and 3H-labeled via 3H2O incorporation) by both groups of cells was
constant for 30 h. Moreover, cells from fasted rats secreted triacylglycerol at rates which
were markedly reduced (mass-84%; 3H-labeled-91%). To assess the relative capacities of …
were used to examine how metabolic state affects lipogenesis, apolipoprotein synthesis,
and the capacity to secrete de novo synthesized triacylglycerol. The secretion of
triacylglycerol (mass and 3H-labeled via 3H2O incorporation) by both groups of cells was
constant for 30 h. Moreover, cells from fasted rats secreted triacylglycerol at rates which
were markedly reduced (mass-84%; 3H-labeled-91%). To assess the relative capacities of …