hBD‐1: a novel β‐defensin from human plasma
KW Bensch, M Raida, HJ Mägert… - FEBS …, 1995 - Wiley Online Library
KW Bensch, M Raida, HJ Mägert, P Schulz-Knappe, WG Forssmann
FEBS letters, 1995•Wiley Online LibraryWe report the isolation and characterization of a novel peptide with significant sequence
homology to β‐defensins from human blood filtrate. The human β‐defensin‐1 (hBD‐1) is a
short basic peptide of 36 amino acid residues. It contains six cysteines forming three
intramolecular disulfide bonds. The molecular mass of hBD‐1 is 3928.6 Da. Cloning of the
specific cDNA confirmed the amino acid sequence of the native peptide. hBD‐1 shares the
nine conserved amino acids characteristic for β‐defensins from respiratory epithelial cells …
homology to β‐defensins from human blood filtrate. The human β‐defensin‐1 (hBD‐1) is a
short basic peptide of 36 amino acid residues. It contains six cysteines forming three
intramolecular disulfide bonds. The molecular mass of hBD‐1 is 3928.6 Da. Cloning of the
specific cDNA confirmed the amino acid sequence of the native peptide. hBD‐1 shares the
nine conserved amino acids characteristic for β‐defensins from respiratory epithelial cells …
We report the isolation and characterization of a novel peptide with significant sequence homology to β‐defensins from human blood filtrate. The human β‐defensin‐1 (hBD‐1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD‐1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide. hBD‐1 shares the nine conserved amino acids characteristic for β‐defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD‐1 is present in nanomolar concentration in human plasma.
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