[CITATION][C] [19] Gene targeting and generation of mutant mice for studies of cell-extracellular matrix interactions

EL George, RO Hynes - Methods in Enzymology, 1994 - Elsevier
The great advances in our understanding of the extracellular matrix (ECM) and its
interactions with cells have relied on the methods used in biochemistry, cell biology, and
molecular biology. These approaches have identified a large number of ECM molecules and
cell surface receptors and have also provided insights into their structures, interactions, and
likely effects on cell behavior. However, it is also necessary to understand the roles of these
proteins in intact organisms during development and in physiological and pathological …