Localization of an apolipoprotein AI epitope critical for activation of lecithin-cholesterol acyltransferase.
CL Banka, DJ Bonnet, AS Black, RS Smith… - Journal of Biological …, 1991 - ASBMB
Apolipoprotein (apo) AI, the major apoprotein of human high density lipoprotein, is a vital
cofactor for lecithin-cholesterol acyltransferase (LCAT), the plasma enzyme responsible for
esterification of free cholesterol associated with high density lipoprotein. This esterification is
an important component of the reverse cholesterol transport process. An immunochemical
approach was used to test the hypothesis that a discrete region of apoA-I was important for
LCAT activation. Three human apoA-I-specific monoclonal antibodies were found to inhibit …
cofactor for lecithin-cholesterol acyltransferase (LCAT), the plasma enzyme responsible for
esterification of free cholesterol associated with high density lipoprotein. This esterification is
an important component of the reverse cholesterol transport process. An immunochemical
approach was used to test the hypothesis that a discrete region of apoA-I was important for
LCAT activation. Three human apoA-I-specific monoclonal antibodies were found to inhibit …