Roles of CCAAT/enhancer-binding protein and its binding site on repression and derepression of acetyl-CoA carboxylase gene.
HJ Tae, X Luo, KH Kim - Journal of Biological Chemistry, 1994 - ASBMB
The gene for acetyl-CoA carboxylase, the rate-limiting enzyme in the biosynthesis of long-
chain fatty acids, contains two distinct promoter regions, denoted PI and PII, which control
the generation of different forms of mRNA. Multiple forms of acetyl-CoA carboxylase (ACC)
mRNA with 5'-end heterogeneity are generated as a result of differential splicing of two
primary transcripts formed under the control of these two promoters. PI is responsible for the
generation of class I mRNAs of ACC, which are induced in a tissue-specific manner under …
chain fatty acids, contains two distinct promoter regions, denoted PI and PII, which control
the generation of different forms of mRNA. Multiple forms of acetyl-CoA carboxylase (ACC)
mRNA with 5'-end heterogeneity are generated as a result of differential splicing of two
primary transcripts formed under the control of these two promoters. PI is responsible for the
generation of class I mRNAs of ACC, which are induced in a tissue-specific manner under …