[HTML][HTML] p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1β
Z Guan, LD Baier, AR Morrison - Journal of Biological Chemistry, 1997 - ASBMB
The inflammatory cytokine interleukin 1β (IL-1β) induces both cyclooxygenase-2 (Cox-2)
and the inducible nitric-oxide synthase (iNOS) with increases in the release of
prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells. However, the
intracellular signaling mechanisms by which IL-1β induces iNOS and Cox-2 expression is
obscure. Our current studies demonstrate that IL-1β produces a rapid increase in p38
mitogen-activated protein kinase (MAPK) phosphorylation and activation. Serum starvation …
and the inducible nitric-oxide synthase (iNOS) with increases in the release of
prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells. However, the
intracellular signaling mechanisms by which IL-1β induces iNOS and Cox-2 expression is
obscure. Our current studies demonstrate that IL-1β produces a rapid increase in p38
mitogen-activated protein kinase (MAPK) phosphorylation and activation. Serum starvation …