[HTML][HTML] Protein kinase C δ activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
Y Ueda, S Hirai, S Osada, A Suzuki, K Mizuno… - Journal of Biological …, 1996 - ASBMB
Although the involvement of protein kinase C (PKC) in the activation of the mitogen-activated
protein (MAP) kinase pathway has been implicated through experiments using 12-O-
tetradecanoylphorbol-13-acetate (TPA), there has been no direct demonstration that PKC
activates the MAP kinase pathway. A Raf-dependent intact cell assay system for monitoring
the activation of MAPK/ERK kinase (MEK) and extracellular signal-related kinase (ERK)
permitted us to evaluate the role of PKC isotypes in MAP kinase activation. Treatment of …
protein (MAP) kinase pathway has been implicated through experiments using 12-O-
tetradecanoylphorbol-13-acetate (TPA), there has been no direct demonstration that PKC
activates the MAP kinase pathway. A Raf-dependent intact cell assay system for monitoring
the activation of MAPK/ERK kinase (MEK) and extracellular signal-related kinase (ERK)
permitted us to evaluate the role of PKC isotypes in MAP kinase activation. Treatment of …