Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications
M Brownlee, A Cerami, H Vlassara - New England Journal of …, 1988 - Mass Medical Soc
M Brownlee, A Cerami, H Vlassara
New England Journal of Medicine, 1988•Mass Medical SocIN this seminar we review recent studies suggesting that the central pathologic features of
diabetic complications are caused by the hyperglycemia-accelerated formation of
nonenzymatic advanced glycosylation end products in tissue. We will emphasize new
research findings with important clinical implications, since older information is available in
previously published reviews. 1, 2 Other biochemical mechanisms by which hyperglycemia
may contribute to the development of diabetic complications are not discussed here, since …
diabetic complications are caused by the hyperglycemia-accelerated formation of
nonenzymatic advanced glycosylation end products in tissue. We will emphasize new
research findings with important clinical implications, since older information is available in
previously published reviews. 1, 2 Other biochemical mechanisms by which hyperglycemia
may contribute to the development of diabetic complications are not discussed here, since …
IN this seminar we review recent studies suggesting that the central pathologic features of diabetic complications are caused by the hyperglycemia-accelerated formation of nonenzymatic advanced glycosylation end products in tissue. We will emphasize new research findings with important clinical implications, since older information is available in previously published reviews.1 , 2 Other biochemical mechanisms by which hyperglycemia may contribute to the development of diabetic complications are not discussed here, since they are comprehensively reviewed elsewhere.3 4 5 6 7 8
Differences between Early and Advanced Glycosylation Products
The central pathophysiologic features of diabetic vascular complications are an abnormal leakage of proteins from the circulation and a progressive . . .
The New England Journal Of Medicine