Requirement for γδ T cells in allergic airway inflammation

C Zuany-Amorim, C Ruffie, S Haile, BB Vargaftig… - Science, 1998 - science.org
C Zuany-Amorim, C Ruffie, S Haile, BB Vargaftig, P Pereira, M Pretolani
Science, 1998science.org
The factors that contribute to allergic asthma are unclear but the resulting condition is
considered a consequence of a type-2 T helper (TH2) cell response. In a model of
pulmonary allergic inflammation, mice that lacked γδ T cells had decreases in specific
immunoglobulin E (IgE) and IgG1 and pulmonary interleukin-5 (IL-5) release as well as in
eosinophil and T cell infiltration compared with wild-type mice. These responses were
restored by administration of IL-4 to γδ T cell-deficient mice during the primary immunization …
The factors that contribute to allergic asthma are unclear but the resulting condition is considered a consequence of a type-2 T helper (TH2) cell response. In a model of pulmonary allergic inflammation, mice that lacked γδ T cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary interleukin-5 (IL-5) release as well as in eosinophil and T cell infiltration compared with wild-type mice. These responses were restored by administration of IL-4 to γδ T cell-deficient mice during the primary immunization. Thus, γδ T cells are essential for inducing IL-4-dependent IgE and IgG1 responses and for TH2-mediated airway inflammation to peptidic antigens.
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