[HTML][HTML] Phosphorylation of the inositol 1, 4, 5-trisphosphate receptor: cyclic GMP-dependent protein kinase mediates cAMP and cGMP dependent phosphorylation in …

P Komalavilas, TM Lincoln - Journal of Biological Chemistry, 1996 - ASBMB
The effects of cyclic GMP (cGMP) and activation of cGMP-dependent protein kinase (PKG)
on the phosphorylation of the inositol 1, 4, 5-trisphosphate (IP 3) receptor were examined in
intact rat aorta using the technique of back phosphorylation. Aorta treated with the nitric
oxide donors, S-nitroso-N-acetylpenicillamine and sodium nitroprusside, or the selective
PKG activator, 8-(4-para-chlorophenylthio)-cGMP (8-CPT-cGMP), demonstrated increased
IP 3 receptor phosphorylation in situ, which was both time-and concentration-dependent …