Studies on diabetic retinopathy: III. Influence of diabetes on intramural pericytes

P Speiser, AM Gittelsohn, A Patz - Archives of Ophthalmology, 1968 - jamanetwork.com
The ratio of endothelial cells to intramural pericytes (E/IMP) in retinas of diabetic patients
and in retinas from various nondiabetic disease groups has been studied. The results show
a specific and highly significant loss of pericytes in diabetes, regardless of age. Loss of
intramural pericytes in diabetes is associated with an increase in ghost cells, shunt vessels,
and the number of microaneurysms.