[HTML][HTML] Critical residues for ligand binding in an I domain-like structure of the integrin β1 subunit
W Puzon-McLaughlin, Y Takada - Journal of Biological Chemistry, 1996 - ASBMB
Several integrin α subunits have an inserted sequence of about 200 residues (the I or A
domain) that is critical for ligand interactions. The presence of an I domain-like structure
within the integrin β subunit has been proposed based on the similarity of the hydropathy
profiles and the homology of sequences between the α and β subunits. This study was
designed to determine whether the region of the β1 subunit that includes residues 101-335
has the characteristics of an I domain. We found novel critical residues for ligand binding …
domain) that is critical for ligand interactions. The presence of an I domain-like structure
within the integrin β subunit has been proposed based on the similarity of the hydropathy
profiles and the homology of sequences between the α and β subunits. This study was
designed to determine whether the region of the β1 subunit that includes residues 101-335
has the characteristics of an I domain. We found novel critical residues for ligand binding …