Regulation of bile acid synthesis by deoxycholic acid in the rat: different effects on cholesterol 7α-hydroxylase and sterol 27-hydroxylase
S Shefer, BT Kren, G Salen, CJ Steer, LB Nguyen… - Hepatology, 1995 - Elsevier
We examined the effects of feeding deoxycholic acid (1% and 0.4% of diet), alone and in
combination with ursodeoxycholic acid, on serum and biliary bile acid concentrations,
hepatic morphology, and the activities and steady-state messenger RNA (mRNA) levels of
HMG-CoA reductase and cholesterol 7α-hydroxylase in the rat. Feeding 1% deoxycholic
acid increased serum bile acid concentrations (cholestasis), produced portal triad
inflammation, bile duct proliferation, and severe hepatocyte necrosis with nuclear …
combination with ursodeoxycholic acid, on serum and biliary bile acid concentrations,
hepatic morphology, and the activities and steady-state messenger RNA (mRNA) levels of
HMG-CoA reductase and cholesterol 7α-hydroxylase in the rat. Feeding 1% deoxycholic
acid increased serum bile acid concentrations (cholestasis), produced portal triad
inflammation, bile duct proliferation, and severe hepatocyte necrosis with nuclear …