Differing effects of cholesterol and taurocholate on steady state hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase activities and mRNA levels in the rat …
S Shefer, LB Nguyen, G Salen, GC Ness… - Journal of lipid …, 1992 - ASBMB
We investigated the effects of cholesterol, cholestyramine, and taurocholate feeding on
steady state specific activities and mRNA levels of hepatic 3-hydroxy-3-methylglutaryl (HMG)-
CoA reductase and cholesterol 7 alpha-hydroxylase in the rat. Interruption of the
enterohepatic circulation of bile acids (cholestyramine feeding) increased total HMG-CoA
reductase activity 5-fold. Cholesterol and taurocholate administration suppressed total
microsomal HMG-CoA reductase activities 87% and 65%, respectively. HMG-CoA reductase …
steady state specific activities and mRNA levels of hepatic 3-hydroxy-3-methylglutaryl (HMG)-
CoA reductase and cholesterol 7 alpha-hydroxylase in the rat. Interruption of the
enterohepatic circulation of bile acids (cholestyramine feeding) increased total HMG-CoA
reductase activity 5-fold. Cholesterol and taurocholate administration suppressed total
microsomal HMG-CoA reductase activities 87% and 65%, respectively. HMG-CoA reductase …