Suppression of anti-glomerular basement membrane nephritis by administration of anti-monocyte chemoattractant protein-1 antibody in WKY rats.
Anti-glomerular basement membrane (GBM) nephritis in WKY rats is characterized by an
accumulation of CD8-positive lymphocytes (CD8+ lym) and monocytes/macrophages (Mo/M
psi) in the glomeruli and crescent formation. In the study presented here, the involvement of
a chemokine for Mo/M psi, monocyte chemoattractant protein-1 (MCP-1), was examined in
this model. An intense induction of mRNA for MCP-1 in the glomeruli and a suppressive
effect of anti-MCP-1 antibody administration on the glomerular Mo/M psi accumulation and …
accumulation of CD8-positive lymphocytes (CD8+ lym) and monocytes/macrophages (Mo/M
psi) in the glomeruli and crescent formation. In the study presented here, the involvement of
a chemokine for Mo/M psi, monocyte chemoattractant protein-1 (MCP-1), was examined in
this model. An intense induction of mRNA for MCP-1 in the glomeruli and a suppressive
effect of anti-MCP-1 antibody administration on the glomerular Mo/M psi accumulation and …