[HTML][HTML] Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule
H Ohnishi, M Kubota, A Ohtake, K Sato… - Journal of Biological …, 1996 - ASBMB
BIT (a brain immunoglobulin-like molecule with tyrosine-based activation motifs) is a brain-
specific membrane protein which has two cytoplasmic TAMs (ayrosine-based activation
motifs). Using the Far Western blotting technique, we detected association of a 70-kDa
protein with the tyrosine-phosphorylated TAMs of BIT. A mouse brain cDNA library in λgt11
was screened for this association, and two positive clones encoding tyrosine phosphatase
SH-PTP2 were isolated. SH-PTP2 has two SH2 domains and is believed to function as a …
specific membrane protein which has two cytoplasmic TAMs (ayrosine-based activation
motifs). Using the Far Western blotting technique, we detected association of a 70-kDa
protein with the tyrosine-phosphorylated TAMs of BIT. A mouse brain cDNA library in λgt11
was screened for this association, and two positive clones encoding tyrosine phosphatase
SH-PTP2 were isolated. SH-PTP2 has two SH2 domains and is believed to function as a …