[HTML][HTML] Tandem SH2 domains confer high specificity in tyrosine kinase signaling
EA Ottinger, MC Botfield, SE Shoelson - Journal of Biological Chemistry, 1998 - ASBMB
SH2 domain proteins transmit intracellular signals initiated by activated tyrosine kinase-
linked receptors. Recent three-dimensional structures suggest mechanisms by which
tandem SH2 domains might confer higher specificity than individual SH2 domains. To test
this, binding studies were conducted with tandem domains from the five signaling enzymes:
phosphatidylinositol 3-kinase p85, ZAP-70, Syk, SHP-2, and phospholipase C-γ1.
Bisphosphorylated TAMs (tyrosine-based activation motifs) were derived from biologically …
linked receptors. Recent three-dimensional structures suggest mechanisms by which
tandem SH2 domains might confer higher specificity than individual SH2 domains. To test
this, binding studies were conducted with tandem domains from the five signaling enzymes:
phosphatidylinositol 3-kinase p85, ZAP-70, Syk, SHP-2, and phospholipase C-γ1.
Bisphosphorylated TAMs (tyrosine-based activation motifs) were derived from biologically …