[HTML][HTML] Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the …
J Sun, J Williams, HC Yan, KM Amin… - Journal of Biological …, 1996 - ASBMB
PECAM-1/CD31 is vascular cell adhesion and signaling molecule of the Ig superfamily that
plays a role in neutrophil recruitment at inflammatory sites and may be involved the release
of leukocytes from the bone marrow and in cardiovascular development. The interactions of
PECAM-1 with its ligands are complex in that it is able to bind both with itself (homophilic
adhesion) or with non-PECAM-1 ligands (heterophilic adhesion). Although the factors that
regulate ligand binding are not fully understood, these interactions are regulated in part by …
plays a role in neutrophil recruitment at inflammatory sites and may be involved the release
of leukocytes from the bone marrow and in cardiovascular development. The interactions of
PECAM-1 with its ligands are complex in that it is able to bind both with itself (homophilic
adhesion) or with non-PECAM-1 ligands (heterophilic adhesion). Although the factors that
regulate ligand binding are not fully understood, these interactions are regulated in part by …