[HTML][HTML] Individually Distinct Ig Homology Domains in PECAM-1 Regulate Homophilic Binding and Modulate Receptor Affinity (∗)
QH Sun, HM DeLisser, MM Zukowski… - Journal of Biological …, 1996 - ASBMB
PECAM-1 (CD31) is a 130-kDa member of the immunoglobulin (Ig) gene superfamily that is
constitutively expressed at high concentration at endothelial cell intercellular junctions and
at moderate density on the surface of circulating leukocytes and platelets. Recent in vitro
and in vivo studies have shown that PECAM-1 plays a central role in mediating the
extravasation of leukocytes from the vessel wall in response to inflammatory mediators. To
study the binding characteristics of PECAM-1, phospholipid vesicles were prepared and …
constitutively expressed at high concentration at endothelial cell intercellular junctions and
at moderate density on the surface of circulating leukocytes and platelets. Recent in vitro
and in vivo studies have shown that PECAM-1 plays a central role in mediating the
extravasation of leukocytes from the vessel wall in response to inflammatory mediators. To
study the binding characteristics of PECAM-1, phospholipid vesicles were prepared and …