[HTML][HTML] The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during …
Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is a homophilic adhesion receptor
that mediates leukocyte/endothelial cell interactions that take place during transendothelial
migration. Recent reports have shown that the binding of certain anti-PECAM-1 antibodies
results in up-regulation of integrin function on the surface of leukocytes and platelets,
suggesting that PECAM-1 may be capable of transmitting information into the cell following
its engagement. PECAM-1 isolated from resting or activated but nonaggregated platelets …
that mediates leukocyte/endothelial cell interactions that take place during transendothelial
migration. Recent reports have shown that the binding of certain anti-PECAM-1 antibodies
results in up-regulation of integrin function on the surface of leukocytes and platelets,
suggesting that PECAM-1 may be capable of transmitting information into the cell following
its engagement. PECAM-1 isolated from resting or activated but nonaggregated platelets …