[HTML][HTML] Protein disulfide isomerase and assisted protein folding
HF Gilbert - Journal of Biological Chemistry, 1997 - ASBMB
The folding protein (and protein folder) is beset with a number of problems in translating the
simple instructions encoded by DNA into the complex, three-dimensional structure of a
correctly folded protein. Nature has solved these problems in an adequate, if not elegant,
fashion, but we are just beginning to understand the variety of strategies that cells use to
ensure efficient protein folding. This minireview will focus on several of the more general
principles of assisted folding using the folding catalyst, protein disulfide isomerase (PDI), 1 …
simple instructions encoded by DNA into the complex, three-dimensional structure of a
correctly folded protein. Nature has solved these problems in an adequate, if not elegant,
fashion, but we are just beginning to understand the variety of strategies that cells use to
ensure efficient protein folding. This minireview will focus on several of the more general
principles of assisted folding using the folding catalyst, protein disulfide isomerase (PDI), 1 …