[HTML][HTML] Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases

MA Musci, LR Hendricks-Taylor, DG Motto… - Journal of Biological …, 1997 - ASBMB
Previous work has demonstrated that SLP-76, a Grb2-associated tyrosine-phosphorylated
protein, augments Interleukin-2 promoter activity when overexpressed in the Jurkat T cell
line. This activity requires regions of SLP-76 that mediate protein-protein interactions with
other molecules in T cells, suggesting that SLP-76-associated proteins also function to
regulate signal transduction. Here we describe the molecular cloning of SLAP-130, a SLP-
76-associated phosphoprotein of 130 kDa. We demonstrate that SLAP-130 is hematopoietic …