Large clostridial cytotoxins—a family of glycosyltransferases modifying small GTP-binding proteins

C von Eichel-Streiber, P Boquet, M Sauerborn… - Trends in …, 1996 - cell.com
C von Eichel-Streiber, P Boquet, M Sauerborn, M Thelestam
Trends in microbiology, 1996cell.com
Clostridiurn botulinum, act on targets in the cytosol. C2 and C3 are ADP-ribosyltransferases;
C2 modifies cellular actin and C3 modifies the small GTP-binding protein Rho (Ref. 2),
which is an important regulator of actin polymerization 3. Clostridial neurotoxins constitute
the best-known group of clostridial toxins, are hom-
Clostridiurn botulinum, act on targets in the cytosol. C2 and C3 are ADP-ribosyltransferases; C2 modifies cellular actin and C3 modifies the small GTP-binding protein Rho (Ref. 2), which is an important regulator of actin polymerization 3. Clostridial neurotoxins constitute the best-known group of clostridial toxins, are hom-
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