[HTML][HTML] Peroxynitrite Inhibits Glutamate Transporter Subtypes (∗)
D Trotti, D Rossi, O Gjesdal, LM Levy, G Racagni… - Journal of Biological …, 1996 - ASBMB
The reuptake of glutamate in neurons and astrocytes terminates excitatory signals and
prevents the persistence of excitotoxic levels of glutamate in the synaptic cleft. This process
is inhibited by oxygen radicals and hydrogen peroxide (H 2 O 2). Here we show that another
biological oxidant, peroxynitrite (ONOO-), formed by combination of superoxide (· O 2-) and
nitric oxide (NO), potently inhibits glutamate uptake by purified or recombinant high affinity
glutamate transporters reconstituted in liposomes. ONOO-reduces selectively the V max of …
prevents the persistence of excitotoxic levels of glutamate in the synaptic cleft. This process
is inhibited by oxygen radicals and hydrogen peroxide (H 2 O 2). Here we show that another
biological oxidant, peroxynitrite (ONOO-), formed by combination of superoxide (· O 2-) and
nitric oxide (NO), potently inhibits glutamate uptake by purified or recombinant high affinity
glutamate transporters reconstituted in liposomes. ONOO-reduces selectively the V max of …