The involvement of glial cells in the development of morphine tolerance
P Song, ZQ Zhao - Neuroscience research, 2001 - Elsevier
Glial response to chronic morphine treatment was examined by immunohistochemistry of
glial fibrillary acidic protein (GFAP), a specific marker for astroglial cells. Systemic
administration of morphine (50 mg/kg, ip) once daily for 9 consecutive days led to significant
increase in GFAP immunostaining density in the spinal cord, posterior cingulate cortex and
hippocampus but not in the thalamus. This increase was attributed primarily to hypertrophy
of astroglial cells rather than their proliferation or migration. When chronic morphine (20 μg/2 …
glial fibrillary acidic protein (GFAP), a specific marker for astroglial cells. Systemic
administration of morphine (50 mg/kg, ip) once daily for 9 consecutive days led to significant
increase in GFAP immunostaining density in the spinal cord, posterior cingulate cortex and
hippocampus but not in the thalamus. This increase was attributed primarily to hypertrophy
of astroglial cells rather than their proliferation or migration. When chronic morphine (20 μg/2 …