Antibodies to vimentin intermediate filaments in sera from patients with systemic lupus erythematosus
A Alcover, J Molano, J Renart… - … : Official Journal of …, 1984 - Wiley Online Library
A Alcover, J Molano, J Renart, A Gil‐Aguado, A Nieto, J Avila
Arthritis & Rheumatism: Official Journal of the American College …, 1984•Wiley Online LibrarySera from patients with systemic lupus erythe‐matosus and from healthy subjects were
tested, using immunofluorescence and blotting techniques, for the presence of antibodies to
intermediate filaments of the cytoskeleton of human skin fibroblasts. Both techniques
showed that antibodies to intermediate filaments were found in a higher proportion of sera
from patients (53%) than healthy subjects (9%). The antigen target was found to be the
protein band that corresponded to vimentin (Mr 57,000).
tested, using immunofluorescence and blotting techniques, for the presence of antibodies to
intermediate filaments of the cytoskeleton of human skin fibroblasts. Both techniques
showed that antibodies to intermediate filaments were found in a higher proportion of sera
from patients (53%) than healthy subjects (9%). The antigen target was found to be the
protein band that corresponded to vimentin (Mr 57,000).
Abstract
Sera from patients with systemic lupus erythe‐matosus and from healthy subjects were tested, using immunofluorescence and blotting techniques, for the presence of antibodies to intermediate filaments of the cytoskeleton of human skin fibroblasts. Both techniques showed that antibodies to intermediate filaments were found in a higher proportion of sera from patients (53%) than healthy subjects (9%). The antigen target was found to be the protein band that corresponded to vimentin (Mr 57,000).
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